- Series:Â Resistance to Targeted Anti-Cancer Therapeutics (Book 13)
- Hardcover:Â 147 pages
- Publisher:Â Springer; 1st ed. 2017 edition (August 15, 2017)
- Language:Â English
Resistance to Molecular Therapies for Hepatocellular Carcinoma (Resistance to Targeted Anti-Cancer Therapeutics)Â 1st ed
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This volume evaluates the clinical patterns of resistance to sorafenib, the impact of trial design in the second-line setting and the current gold standard to define radiological resistance; describes the molecular mechanisms responsible for treatment resistance in HCC patients, including components of the immune system and tumor microenvironment; determines the role of the cancer stem cell phenotype in resistance; reviews the experimental models to study resistance; and addresses new approaches to overcome resistance to sorafenib, using successful examples from other malignancies.Â
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