Clinics and Research in Hepatology and Gastroenterology Volume 45, Issue 4 2021 (original pdf)

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Clinics and Research in Hepatology and Gastroenterology Volume 45, Issue 4 2021 (original pdf)

Articles in this issue:

  1.   Editorial board

  2.   The endless history or search for the true role of alloantibodies in liver transplantation

    Article 101544. Muro, Manuel.

    The clear role of donor-specific anti-HLA antibodies (DSA) is recognized in most transplants with the sole exception of the liver. This is a classically “immunologically privileged” organ and it is well known that, due to their special allogeneic …

  3.   In vivo endoscopic blood flow visualization by magnified blue laser imaging

    Article 101577. Zimmer, Vincent.

    High-quality image-enhanced endoscopy has opened up altogether novel perspectives on mucosal surface, vascular pattern and pathology in recent years, which is even more true when combined with magnification endoscopy. Multi-light illumination tech…

  4.   Stones in the esophagus

    Article 101582. Zimmer, Vincent.

    A 69-year-old institutionalized male patient with alcoholic disease and Korsakoff syndrome first presented with an estimated 30-mm large esophageal perforation complicating bolus impaction. At the time, the patient underwent stenting using a 28 × …

     

  5.   Iatrogenic bilhemia after transjugular portal stent placement

    Article 101597. Quénéhervé, Lucille, Imbert, Astrid, Douane, Frédéric, Archambeaud, Isabelle, Gournay, Jérôme, and Coron, Emmanuel.

    A 53-year-old man was admitted to our liver unit for a rapid increase in serum bilirubin after a vascular procedure for alcohol-related chronic pancreatitis. The patient had undergone transjugular spleno-portal and mesenteric-portal stent placemen…

  6.   Pressurized submucosal water infusion as a novel endoscopic principle to optimize defect margin assessment after cold snare mucosectomy

    Article 101642. Zimmer, V..

    Given its speed and ease in use, cold snare polypectomy/mucosectomy (CSP/CSM) has been widely embraced in clinical endoscopy practice for colorectal lesions and is recommended by authorative international guidelines [1]. Though visual control of l…

      High-quality endoscopic perspective on pseudomelanosis ilei: underwater, magnified and image-enhanced

    Article 101643. Zimmer, Vincent, and Emrich, Kai.

    A 26-year-old male patient was admitted due to a flare of previously diagnosed ulcerative colitis (UC). After exclusion of superimposed infection, the patient underwent ileocolonoscopy revealing severe left-sided UC (Mayo Endoscopic Score 3), and …

  7.   Muscle mass depletion in chronic liver diseases: An accelerated model of aging or a distinct entity?

    Article 101721. Lanthier, Nicolas, Stärkel, Peter, and Dahlqvist, Géraldine.

    AbstractSarcopenia was initially defined as loss of muscle mass, strength and function related to aging. This phenomenon is a multifactorial process. The evaluation of the geriatric population in which sarcopenia has extensively been studied opens…

  8.   Treatment of hepatitis C virus infection

    Article 101578. Parlati, Lucia, Hollande, Clémence, and Pol, Stanislas.

    AbstractHepatitis C virus infection affects 71 million people worldwide. It is at the origin of a multi-organ disease associating hepatic manifestations, cryoglobulinemic vasculitis and general manifestations linked to chronic inflammation (diabet…

  9.   Pathogenetic mechanisms of nonalcoholic fatty liver disease and inhibition of the inflammasome as a new therapeutic target

    Article 101710. Colak, Yasar, Hasan, Badar, Erkalma, Banu, Tandon, Kanwarpreet, Zervos, Xaralambos, Menzo, Emanuele Lo, and Erim, Tolga.

    Highlights•The nonalcoholic fatty disease is currently the most common liver disease in the United States. •Lifestyle modification remains the primary therapy as no pharmacological therapy has been approved. •NLR family pyrin domain-containing pro…

  10.   Angioedema with severe acute abdominal pain: Think of hereditary angioedema

    Article 101702. Mumneh, Nayla, Tick, Matthew, and Borum, Marie.

    Highlights•Intestinal angioedema (IA) can mimic other causes of acute abdominal pain. •IA can be histamine- or bradykinin-mediated, with distinct treatment requirements. •Hereditary angioedema (HAE) is a rare form of bradykinin-mediated angioedema…

  11.   Prevalence and clinical features of hepatitis E virus infection in pregnant women: A large cohort study in Inner Mongolia, China

    Article 101536. Ma, Xiao-xia, Ji, Yunpeng, Jin, Li, Baloch, Zulqarnain, Zhang, De-rong, Wang, Yijin, Pan, Qiuwei, and Ma, Zhongren.

    Highlights•6% of past HEV infection and 0.6% of recent/ongoing infection in Chinese pregnant women •Ongoing/recent infection appears to associate with adverse maternal and neonatal outcomes. •Future research is warranted to further confirm our fin…

  12.   Drug-eluting bead transarterial chemoembolization is an effective downstaging option for subsequent radical treatments in patients with hepatocellular carcinoma: A cohort study

    Article 101535. Cai, Liang, Li, Honglu, Guo, Jiang, Zhao, Wenpeng, Duan, Youjia, Hou, Xiaopu, Cheng, Long, Du, Hongliu, Shao, Xihong, Diao, Zhenying, and Li, Changqing.

    Highlights•59.4% unresectable HCC patients had successful down-staging after DEB-TACE, and followed radical treatment reached CR of 81.3%. •CNLC stage (IIb vs. IIa) was an independent factor for non-successful down-stating in unresectable HCC pati…

     

  13.   A novel online calculator based on noninvasive markers (ALBI and APRI) for predicting post-hepatectomy liver failure in patients with hepatocellular carcinoma

    Article 101534. Shi, Jin-Yu, Sun, Li-Yang, Quan, Bing, Xing, Hao, Li, Chao, Liang, Lei, Pawlik, Timothy M., Zhou, Ya-Hao, Wang, Hong, Gu, Wei-Min, Chen, Ting-Hao, Lau, Wan Yee, Shen, Feng, Wang, Nan-Ya, and Yang, Tian.

    Highlights•Post-hepatectomy liver failure (PHLF) is a devastating complication. •Multivariable analysis identified high ALBI and APRI grades as independent risks of PHLF in both pre- and postoperative models. •The AUCs for the pre- and postoperati…

  14.   Modified AST to platelet ratio index improves APRI and better predicts advanced fibrosis and liver cirrhosis in patients with non-alcoholic fatty liver disease

    Article 101528. Huang, Cheryl, Seah, Jun Jie, Tan, Chin Kimg, Kam, Jia Wen, Tan, Jessica, Teo, Eng Kiong, Kwek, Andrew, Wong, Yu Jun, Tan, Malcolm, Ang, Tiing Leong, and Kumar, Rahul.

    Highlights•m-APRI, a non-invasive tool, can predict the presence or absence of advanced fibrosis and liver cirrhosis with accuracy. •m-APRI performs better than APRI and BARD in predicting both advanced fibrosis and liver cirrhosis in NAFLD. •The …

      The clinical value of kinesin superfamily protein 2A in hepatocellular carcinoma

    Article 101527. Liu, Wenjuan, Xu, Chunlin, Meng, Qingyang, and Kang, Peng.

    Highlights•KIF2A is upregulated in tumor tissue compared to adjacent tissue. •Tumor KIF2A is associated with worse liver function as well as raised tumor stage in HCC patients. •Tumor KIF2A severs as an independent factor predicting poor OS in HCC…

  15. Systematic review on the prevalence of nonalcoholic fatty liver disease in South Korea  Download PDF

    Article 101526. Im, Hwi Jin, Ahn, Yo Chan, Wang, Jing-Hua, Lee, Myung Min, and Son, Chang Gue.

    Highlights•The current study is the first systematic review on NAFLD prevalence in Korea. •The overall NAFLD prevalence in Korea was 30.3% as two-fold higher in men (41.4%) than women (20.3%). •The prevalence of NAFLD in Korea was further analyzed…

      Prevalence and clinical characteristics of alpha-1 antitrypsin deficiency in liver explants in a Mexican cohort

    Article 101519. Campos-Murguía, Alejandro, Valdéz-Hernández, Pedro, Cordova-Gallardo, Jacqueline, Arteaga-Vázquez, Jazmín, Contreras, Alan G., Vilatobá, Mario, Cruz-Martínez, Rodrigo, Martínez-Benítez, Braulio, Gamboa-Domínguez, Armando, Marfil-Garza, Braulio A., Flores-García, Nayelli C., Márquez-Guillén, Ernesto, and García-Juárez, Ignacio.

    Highlights•α1 antitrypsin deficiency is an unrecognized cause of liver disease. •α1 antitrypsin deficiency was found unexpectedly in 4.5% of liver explants. •Heterozygous variants were found in all patients with α1 antitrypsin deficiency. •Coexist…

  16.   De novo hepatocellular carcinoma in cirrhotic hepatitis C virus: Are directly acting antivirals beneficial?

    Article 101517. Montasser, Iman F., Ibrahim, Amany A., Farid, Hoda M., and Al Balakosy, Amira M..

    Highlights•Impact of chronic HCV treatment by DAAs on HCC is controversial. •De novo HCC characteristics were compared between patients treated and untreated with DAAs. •No difference in BCLC staging in DAAs exposed and unexposed patients. Summary…

  17.   Risk factors of de novo malignancies after liver transplantation: a French national study on 11004 adult patients

    Article 101514. Altieri, Mario, Sérée, Olivier, Lobbedez, Thierry, Segol, Philippe, Abergel, Armand, Blaizot, Xavier, Boillot, Olivier, Boudjema, Karim, Coilly, Audrey, Conti, Filomena, Chazouillères, Olivier, Debette-Gratien, Maryline, Dharancy, Sébastien, Durand, François, Duvoux, Christophe, Francoz, Claire, Gugenheim, Jean, Hardwigsen, Jean, Houssel-Debry, Pauline, Kamar, Nassim, Latournerie, Marianne, Lebray, Pascal, Leroy, Vincent, Neau-Cransac, Martine, Pageaux, Georges-Philippe, Radenne, Sylvie, Salamé, Ephrem, Saliba, Faouzi, Samuel, Didier, Vanlemmens, Claire, Besch, Camille, Launoy, Guy, and Dumortier, Jérôme.

    Highlights•After liver transplantation (LT), de novo malignancies are one of the leading causes of late mortality. •Risk factors of de novo malignancies in a large cohort of LT recipients (n=11004) are described using Fine and Gray competing risks…

  18.   Do renin-angiotensin system inhibitors reduce risk for hepatocellular carcinoma?: A nationwide nested case-control study

    Article 101510. Kim, Kwang Min, Roh, Ji Hye, Lee, Sangjin, and Yoon, Jeong-Hyun.

    Highlights•A much-debated question is whether renin-angiotensin system inhibitors (RASi) have any beneficial effects in patients with HCC. •The present study did not prove a significant association between RASi use and HCC across the entire cohort…

  19.   Impact of the first Covid-19 outbreak on liver transplantation activity in France: A snapshot

    Article 101560. Turco, Célia, Lim, Chetana, Soubrane, Olivier, Malaquin, Géraldine, Kerbaul, François, Bastien, Olivier, Conti, Filomena, and Scatton, Olivier.

    Highlights•The global pandemic of Coronavirus Disease 2019 has drastically affected liver transplantation programs worldwide. •There was a significant decrease in the number of organ donations and liver transplantations performed in France. •The N…

     

  20.   Covid-19 in liver transplant recipients: the French SOT COVID registry

    Article 101639. Dumortier, Jérôme, Duvoux, Christophe, Roux, Olivier, Altieri, Mario, Barraud, Hélène, Besch, Camille, Caillard, Sophie, Coilly, Audrey, Conti, Filomena, Dharancy, Sébastien, Durand, François, Francoz, Claire, Garaix, Florentine, Houssel-Debry, Pauline, Kounis, Ilias, Lassailly, Guillaume, Laverdure, Noémie, Leroy, Vincent, Mallet, Maxime, Mazzola, Alessandra, Meunier, Lucy, Radenne, Sylvie, Richardet, Jean-Philippe, Vanlemmens, Claire, Hazzan, Marc, and Saliba, Faouzi.

    Highlights•Coronavirus disease-2019 (Covid-19) is an ongoing global pandemic of major concern. •Available data on clinical presentation and prognosis in liver transplant (LT) recipients remains limited. •Disease presentation, immunosuppression man…

  21.   Low serum alkaline phosphatase levels in patients with chronic liver diseases: Possible contributions to disease pathogenesis

    Article 101694. Iluz-Freundlich, Daniel, Grubert Van Iderstine, Micah, Uhanova, Julia, Zhang, Manna, Knowles, Cori, and Minuk, Gerald Y..

    Highlights•Persistently low serum ALP levels are found in 0.25% of liver disease patients. •Low serum ALP levels are associated with attenuated serum aminotransferase and bilirubin levels. •ALP expression may impact the severity and course of chro…

  22.   B-cell compartment abnormalities are associated with ACLF and mortality in patients with liver cirrhosis

    Article 101698. Cardoso, Chandra Chiappin, Matiollo, Camila, Pereira, Carolina Hilgert Jacobsen, Fonseca, Janaina Sant’ana, Alves, Helder Emmanuel Leite, Silva, Otavio Marcos da, Menegassi, Vivian de Souza, Schiavon, Leonardo de Lucca, and Santos-Silva, Maria Claudia.

    Highlights•B-cell compartment is deeply altered in cirrhotic patients. •Cirrhotic patients with ACLF have increased proportions of double-negative B cells. •Transitional B cells are markedly reduced in patients that died in one year. AbstractBackg…

  23.   Impact of sarcopenia on clinical outcomes of patients undergoing simultaneous liver and kidney transplantation: a cohort study

    Article 101692. Mazzola, Alessandra, Brustia, Raffaele, Magro, Bianca, Atif, Muhammad, Ouali, Nassera, Tourret, Jérôme, Barrou, Benoit, Scatton, Olivier, and Conti, Filomena.

    Highlights•Sarcopenia is associated with an increased risk of infections and mortality post-LT. •No data are available on the impact of sarcopenia in SLKT recipients. •Sarcopenia threshold was defined as TPA 24 h, ICU stay >5 days, hospital stay >…

  24.   Diagnostic yield of esophagogastroduodenoscopy in France

    Article 101540. Barret, Maximilien, Chaussade, Stanislas, Boustière, Christian, Canard, Jean-Marc, Schott, Anne-Marie, Ponchon, Thierry, Rahmi, Gabriel, and Cellier, Christophe.

    Highlights•Over 1 000 000 esophagogastroduodenoscopies are performed annually in France. •Barrett’s esophagus is diagnosed in 4% of all esophagogastroduodenoscopies. •Esophageal or gastric neoplasms account for 2.2% of all diagnoses. •33% of these…

  25.   The relationship between cardiac muscularis propria and clinical outcomes of peroral endoscopic myotomy in achalasia

    Article 101529. He, Qing-lin, Chen, Xiu-bing, Lu, Dong-hong, Luo, Wei, Tao, Lin, Ning, Hong-jian, Tang, Shao-mei, Peng, Yi-ling, Qin, Shan-yu, and Jiang, Hai-xing.

    Highlights•A study included the largest sample size of achalasia patients investigated using EUS. •A study offered new insights into the contributions of EUS in achalasia. •Cardiac muscularis propria was a potential risk factor for POEM failure. A…

      Abnormal post-prandial glucagon-like peptide release in patients with Crohn’s disease

    Article 101533. Lucotti, Pietro, Lovati, Elisabetta, Lenti, Marco Vincenzo, Valvo, Beatrice, Sprio, Elisa, Aronico, Nicola, Giuffrida, Paolo, Dell’Aera, Dominica, Pasini, Alessandra, Ubezio, Cristina, Delliponti, Mariangela, Tinelli, Carmine, Corazza, Gino Roberto, and Di Sabatino, Antonio.

    Highlights•What is already known on this subject? •Glucagon-like peptide (GLP)-1 and -2 have been shown to regulate immune responses in immune-mediated disorders, such as Crohn’s disease (CD) •What are the new findings? •Basal GLP-1 levels were up…

  26.   Effect of N-acetylcysteine on remission maintenance in patients with ulcerative colitis: A randomized, double-blind controlled clinical trial

    Article 101532. Masnadi Shirazi, Kourosh, Sotoudeh, Simin, Masnadi Shirazi, Arman, Moaddab, Seyyed-Yaghoub, Nourpanah, Zahra, and Nikniaz, Zeinab.

    Highlights•we assessed the effect of NAC on remission maintenance in patients with UC •There was a significant difference between the NAC and placebo groups regarding the relapse-free period. •Compared with the NAC group (6.1%), significantly more…

  27.   Vitamin D deficiency negatively affects both the intestinal epithelial integrity and bone metabolism in children with Celiac disease

    Article 101523. Aydemir, Yusuf, Assistant Professor, Erdogan, Bahattin, and Türkeli, Ahmet, Assistant Professor.

    Highlights•Vitamin D deficiency is common among children with Celiac disease. •Expression of VDR and epithelial barrier proteins was decreased in children with Celiac disease. •Vitamin D deficiency was related to decreased expression of VDR and ep…

  28.   MiR-142 suppresses progression of gastric carcinoma via directly targeting LRP8

    Article 101520. Lu, Junfeng, Ma, Yanhong, and Zhao, Zhongsong.

    Highlights•MiR-142 expression is reduced in GC tissues and cells. •MiR-142 inhibits cell proliferation and in vivo tumor growth. •MiR-142 inhibits EMT, migration and invasion. •MiR-142 directly targets LRP8. SummaryRecently, the role of miRNA-142 …

  29.   The longitudinal changes of anxiety and depression, their related risk factors and prognostic value in colorectal cancer survivors: a 36-month follow-up study

    Article 101511. Zhou, Lijuan, and Sun, Hui.

    Highlights•Post-operative anxiety and depression are highly prevalent in CRC patients after resection. •Post-operative anxiety and depression continuously progress with time. •Baseline/1-year anxiety are associated with worse prognosis. •Baseline/…

  30.   Long noncoding RNA PVT1 promotes tumour progression via the miR-128/ZEB1 axis and predicts poor prognosis in esophageal cancer

    Article 101701. Hu, Jing, and Gao, Weifang.

    Highlights•PVT1 both in cancer tissues and serum was significantly correlated with OS and MFS. •Knockdown of PVT1 significantly decreased the cell proliferation, migration and invasion of ESCC. •Knockdown of miR-128 recovered the altered prolifera…

  31.   A predictive score of inadequate bowel preparation based on a self-administered questionnaire: PREPA-CO

    Article 101693. Berger, Arthur, Cesbron-Métivier, Elodie, Bertrais, Sandrine, Olivier, Anne, Becq, Aymeric, Boursier, Jèrôme, Lannes, Adrien, Luet, Dominique, Pateu, Etienne, Dib, Nina, Caroli-Bosc, François-Xavier, Vitellius, Carole, and Calès, Paul.

    Highlights•The proportion of patients with inadequate bowel preparation is around 25%, generating significant costs due to repeat procedures. •In this prospective study, risk factors of inadequate bowel preparation were identified. •A predictive s…

  32.   Prevalence and prognosis of microsatellite instability in oesogastric adenocarcinoma, NORDICAP 16-01

    Article 101691. Tran-Minh, My-Linh, Lehmann-Che, Jacqueline, Lambert, Jerôme, Theou-Anton, Nathalie, Poté, Nicolas, Dior, Marie, Mary, Florence, Goujon, Gael, Gardair, Charlotte, Schischmanoff, Olivier, Kaci, Rachid, Cucherousset, Nahla, Bertheau, Philippe, Couvelard, Anne, and Aparicio, Thomas.

    Highlights•Microsatellite instability prevalence is 12.4%. •Patients in MSI group have a lower cumulative incidence of recurrence after surgery. •There is a 100% concordance between molecular analysis and IHC to determine MSI. •Tumors with MSI phe…

  33.   Vedolizumab for steroid & infliximab refractory immune checkpoint inhibitor associated colitis

    Article 101604. Klemm, Natasha, Trasolini, Roberto, Chahal, Daljeet, and Donnellan, Fergal.

    The GEMINI trials demonstrated the benefit of vedolizumab on clinical outcomes in moderate-to-severe ulcerative colitis and Crohn’s disease [1,2]. Subsequently, the VARSITY trial went further to show endoscopic, radiologic and histologic healing i…

  34.   Chromogranin A and NSE in cystic pancreatic neuroendocrine tumors

    Article 101601. Faias, Sandra, Prazeres, Susana, Cunha, Mario, Pereira, Luisa, Roque, Ruben, Chaves, Paula, Cravo, Marília, Claro, Isabel, Silveira, Margarida, Leite, Valeriano, and Dias Pereira, A..

    Highlights•Endoscopic ultrasound fine-needle aspiration (EUS-FNA) with cytology is the standard pre-operative diagnosis of cystic pancreatic neuroendocrine tumors (cPanNETs). •Elevated Chromogranin A and NSE in pancreatic cyst fluid accurately ide…

  35.   Citrin deficiency: Early severe cases in a European country

    Article 101595. Fernández Tomé, Lorena, Stark Aroeira, Luiz Guilherme, Muñoz Bartolo, Gema, de la Vega Bueno, Angela, Camarena Grande, Carmen, Frauca Remacha, Esteban, Lledín Barbancho, Dolores, Alós Díez, María, Quiles Blanco, María José, Guerra, Laura, López Santamaría, Manuel, and Hierro Llanillo, Loreto.

    Citrin deficiency is an inborn error of metabolism with a functional deficit of the mitochondrial glutamate-aspartate carrier called citrin, which plays a key role in the malate-aspartate NADH shuttle, the urea cycle and gluconeogenesis. The disea…

  36.   Hepatitis A seroprevalence in homeless persons, in Marseille, France

    Article 101571. Ly, Tran Duc Anh, Hoang, Van Thuan, Dao, Thi Loi, Badiaga, Sekene, Tissot-Dupont, Herve, Brouqui, Philippe, Colson, Philippe, and Gautret, Philippe.

    In the USA, homeless persons sleeping on the street, outdoors in vehicles or in abandoned buildings are considered at high risk of hepatitis A (as the result of exposure to unhygienic environments) [1]. Previous epidemiological surveys carried out…

  37.   Metamizole-induced acute liver failure in a boy

    Article 101570. Liu, Jie, Dai, Xiao-Ling, Zhou, Xiang-Jun, Gu, Bao-Huan, Yang, Zhen-Hui, and Lai, Jing.

    Metamizole, also known as dipyrone, was launched commercially by Hoechst AG in 1922 and classified as a nonsteroidal antinflammatory drug (NSAID) [1]. Due to its excellent analgesic, antipyretic, and spasmolytic properties combined with its favora…

  38.   DIPS, a safe and effective alternative in patients with unfavorable anatomy to TIPSS: first experience in a tertiary center

    Article 101715. Moschouri, Eleni, Hocquelet, Arnaud, Vermersch, Mathilde, Fraga, Montserrat, Denys, Alban, and Artru, Florent.

    Transjugular intrahepatic portosystemic shunt (TIPSS) is a recognized approach to treat severe portal hypertension (PH) [1–3]. Regularly, TIPSS is not feasible due to unfavorable anatomy. In this situation, the only non-surgical alternative is the…

      Contraceptive vaginal ring-induced cholestasis in a patient with a history of intrahepatic cholestasis of pregnancy

    Article 101475. Perrault, Florence, Echelard, Philippe, Viens, Daniel, and Borduas, Martin.

    Highlights•Patients with a history of intrahepatic cholestasis of pregnancy are at risk of developing contraceptive-induced cholestasis, especially if they harbor a biliary transporter mutation. •Contraceptive-induced cholestasis is a diagnosis of…

  39. Enhancing digestive fistula healing by the off-label use of a thermoresponsive vessel occluder polymer associated with esophageal stent placement: A case report

    Article 101474. Berger, Arthur, Caudron, Eric, Perrod, Guillaume, Boucenna, Imane, Gazeau, Florence, Wilhelm, Claire, Berger, Anne, Clément, Olivier, Cellier, Christophe, Silva, Amanda K.A., and Rahmi, Gabriel.

    SummaryThis case report relates to the first-in-man use of a vessel occluder gel medical device as a fistula occluder in a repurposing strategy. A patient with chronic colocutaneous fistula received an off-label treatment with a thermoresponsive P… 

  40.   A case series of eosinophilic esophagitis and primary adrenal insufficiency

    Article 101699. Kwon, Josh, Koop, Andree, Meek, Shon, and Francis, Dawn.

    AbstractAlthough previously associated with secondary adrenal insufficiency and other autoimmune diseases, eosinophilic esophagitis has not been described in patients with primary adrenal insufficiency. In this case series, we describe three patie…

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